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ogg1 activity  (MedChemExpress)


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    MedChemExpress ogg1 activity
    Ogg1 Activity, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ogg1 activity/product/MedChemExpress
    Average 93 stars, based on 6 article reviews
    ogg1 activity - by Bioz Stars, 2026-02
    93/100 stars

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    FIGURE 3. Activation of <t>OGG1</t> inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
    Ogg1 Activator, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    FIGURE 3. Activation of <t>OGG1</t> inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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    FIGURE 3. Activation of <t>OGG1</t> inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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    FIGURE 3. Activation of <t>OGG1</t> inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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    FIGURE 3. Activation of <t>OGG1</t> inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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    FIGURE 3. Activation of <t>OGG1</t> inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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    Image Search Results


    FIGURE 3. Activation of OGG1 inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Journal: Investigative ophthalmology & visual science

    Article Title: Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract.

    doi: 10.1167/iovs.66.1.29

    Figure Lengend Snippet: FIGURE 3. Activation of OGG1 inhibits ROS-induced LEC paraptosis. (A) Representative immunofluorescence images of indicated LECs against 8-oxoG. (B) Quantification and statistical analysis of 8-oxoG fluorescence intensity. (C, D) The Western blot images and statistical analysis display the relative protein expression levels of OGG1, normalized to β-actin, after treatment with 50 μM H2O2 for 24 hours. (E) Representative confocal images of OGG1-mCherry LECs following treatment at the indicated time points after laser micro-irradiation sites pointed by white arrows. (F) Connecting lines of mean values representing OGG1-mCherry recruitment kinetics. (G, H) The Western blot images and statistical analysis display the relative protein expression levels of ALIX, GRP78, p-ERK, and p-P38, normalized to β-actin. (I) ER and mitochondria were labeled with ER-Tracker green and Mito-Tracker red, respectively, after LECs were treated as indicated. Red arrowheads indicate the dilated ER. (K) Quantification and statistical analysis of intracellular vesicles. (J, L) Representative images of ROS generation and statistical results of indicated LECs treated with 50 μM H2O2 and 10 μM TH10785. Data are displayed as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Article Snippet: TH10785 (MCE), an OGG1 activator, was used at 10 μM for 8 hours.

    Techniques: Activation Assay, Immunofluorescence, Fluorescence, Western Blot, Expressing, Irradiation, Labeling

    FIGURE 5. Schematic illustrating the mechanism of ROS-induced paraptosis in LECs of early ARCC patients. This comprehensive mechanism reveals that the elevated ROS orchestrates a cascade of cellular events, including ER stress induction, IGFIR activation, and subsequent mitogen-activated protein kinase pathway signaling. These molecular events result in ER dilation-formed intracellular vesicles and, ultimately, paraptosis in LECs. Notably, TH10785-mediated enhancement of OGG1 activity effectively suppresses ROS-induced paraptosis and vacuolar degeneration in the superficial lens cortex. AC, anterior chamber; C, cornea; CB, ciliary body; I, iris; N, nucleus; PC, posterior chamber; V, vacuoles.

    Journal: Investigative ophthalmology & visual science

    Article Title: Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract.

    doi: 10.1167/iovs.66.1.29

    Figure Lengend Snippet: FIGURE 5. Schematic illustrating the mechanism of ROS-induced paraptosis in LECs of early ARCC patients. This comprehensive mechanism reveals that the elevated ROS orchestrates a cascade of cellular events, including ER stress induction, IGFIR activation, and subsequent mitogen-activated protein kinase pathway signaling. These molecular events result in ER dilation-formed intracellular vesicles and, ultimately, paraptosis in LECs. Notably, TH10785-mediated enhancement of OGG1 activity effectively suppresses ROS-induced paraptosis and vacuolar degeneration in the superficial lens cortex. AC, anterior chamber; C, cornea; CB, ciliary body; I, iris; N, nucleus; PC, posterior chamber; V, vacuoles.

    Article Snippet: TH10785 (MCE), an OGG1 activator, was used at 10 μM for 8 hours.

    Techniques: Activation Assay, Activity Assay